The Conference of European Cross-border and interregional City Networks – CECICN was born in 2010. Its objective is to boost territorial cooperation among border cities in Europe and to reinforce the message concerning the importance of territorial cooperation. CECICN is comprised of six cooperating networks that represent more than 500 cities in border regions and 37% of European population. Europe is at a crucial moment for future territorial cooperation. In a context of crisis Europe is now working on the budget for the next seven years (2014-2020) and new regulations on Cohesion Policy. Therefore, it is of major importance to reinforce what the benefits of cooperation are, what opportunities it represents and how, through cooperation, Europe can overcome the challenges it faces in the near future. Cooperation is the key to achieve Europe2020 goals.